The Helfrich functional is a mathematical expression proposed by Helfrich (1973) for the natural free energy carried by an elastic phospholipid bilayer. Helfrich theorises that idealised elastic phospholipid bilayers minimise the Helfrich functional among all possible configurations. The functional integrates a spontaneous curvature parameter together with the mean curvature of the bilayer and constraints on area and volume, either through an inclusion of osmotic pressure difference and tensile stress or otherwise. Using the mathematical concept of embedded orientable surface to represent the configuration of the bilayer, one might expect to be able to adapt methods from differential geometry and the calculus of variations to perform a fine analysis of bilayer configurations in terms of the parameters that it depends upon. In this talk we focus upon the case of spherical red blood cells with a view to better understanding spherocytes and spherocytosis. We provide a complete classification of spherical solutions in terms of the parameters in the Helfrich model. We additionally present some further analysis on the rigidity and stability of spherocytes.
This is joint work with Yann Bernard and Glen Wheeler.