Dear All, We are delighted to present the MaPSS Seminar topic of Monday 28/08; please see the abstract below. **This Semester the Seminar will always run on Monday, at 5:00pm in 535A** Following the talk, there will be pizza on offer. Speaker: Adrianne Jenner (Sydney University) Title: How does pressure within a tumour affect the outcome of cancer treatment? Abstract: Pressure within tumour’s has been identified as one of the major culprits impeding cancer treatments. Tumour pressure is known to result in heterogeneous intratumoural distribution of cancer treatments and increase the metastatic potential of tumours. We use a sytem of ODEs to initially optimise in vitro data. We introduce heterogeneous population characteristics into our model through the use of gamma distributions. From this we then build an off-lattice agent based model for the interaction between tumour cells and a cancer treatment. Investigations are undertaken into the optimisation potential of pressure reducing treatments combined with alternate treatment application profiles to discern how to enhance homogeneous treatment diffusion without allowing the formation of metastasis. Supervisors, please encourage your students to attend. Thanks, MaPSS Organizers