Speaker: Dr Ye Ella Tian (University of Melbourne) Abstract: Integrated research into brain and body systems holds substantial clinical potential in addressing multimorbidity and physical illness burden in people with neuropsychiatric disorders. In the first part of my talk, I will introduce a multiorgan aging network to demonstrate how the aging of one organ system selectively and characteristically influences the aging of other brain and body systems. I will show multiorgan aging profiles for 16 chronic brain and body disorders and its relationship to mortality risk prediction. Paper link: https://www.nature.com/articles/s41591-023-02296-6 In the second part of my talk, I will present a multiorgan, system-wide characterization of brain and body health for common neuropsychiatric disorders. I will show that individuals diagnosed with these neuropsychiatric disorders are not only characterized by deviations from normative reference ranges for brain phenotypes but also present considerably poorer physical health across multiple body systems compared to their healthy peers. I will show that poor physical health is a more pronounced manifestation of neuropsychiatric illness compared to brain changes. To close the talk, I will call for integrated and holistic mental and physical health care in psychiatry. Paper link: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2804355 About the speaker: Dr Ye Ella Tian is an NHMRC Emerging Leadership Fellow at the Department of Psychiatry, The University of Melbourne. She is a psychiatrist and neuroscientist by training and holds a PhD in systems neuroscience. She works at the interface between neuroscience, computation and translational research of applying brain imaging techniques to clinical research. She leads the development of the Melbourne Subcortex Atlas. Her current research focuses on brain-body relationships in mental illness across the lifespan. This event will be held online. Zoom: https://uni-sydney.zoom.us/j/84087321707