Statistics Seminar: Uri Keich -- Confidently estimating the number of ARSs (it’s not as bad as it sounds...)

Uri Keich School of Mathematics and Statistics University of Sydney 

Location: Carslaw 173 

Time: 2pm Friday, August 21, 2009 

Title: Confidently estimating the number of ARSs (it’s not as bad as it sounds...)  

Abstract: Eukaryotic chromosomes initiate DNA synthesis from multiple replication
origins.  To date, the Saccharomyces cerevisiae replication origins map is the only
genome map available.  Using an iterative approach that combines computational
prediction and functional validation we have generated a high-resolution genome-wide map
of DNA replication origins in Kluyveromyces lactis.  To reliably estimate how complete
is our coverage we developed a method that applies more broadly for estimating and
providing a confidence interval for the number of functional binding sites.  Most of the
talk will be dedicated to the statistical aspects of the work and the relevant
biological terminology will be explained.  

Joint work with Ivan Liachko, Anand Bhaskar, Chanmi Lee, Shau Chee Claire Chung, and
Bik-Kwoon Tye